Predictive value of net water uptake with respect to early neurological improvement after endovascular treatment in patients with acute anterior circulation large vessel occlusion stroke
10.3760/cma.j.cn112138-20230129-00039
- VernacularTitle:水摄取率对急性前循环大血管闭塞性卒中患者血管内治疗后早期神经功能改善的预测价值
- Author:
Anyu LIAO
1
;
Hang WU
;
Xiaoqing CHENG
;
Lulu XIAO
;
Kangmo HUANG
;
Mengxia LU
;
Liangyuan PAN
;
Kasaer FEILUOLA
;
Yangyang JIANG
;
Zhihui LIU
;
Wusheng ZHU
Author Information
1. 南京大学医学院附属金陵医院（东部战区总医院）神经内科，南京210002
- Keywords:
Stroke;
Net water uptake;
Endovascular procedures;
Early neurological improvement
- From:
Chinese Journal of Internal Medicine
2023;62(10):1172-1177
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of net water uptake (NWU) for predicting early neurological improvement (ENI) after endovascular treatment in patients with acute anterior circulation large vessel occlusion stroke.Methods:A case-control study. A total of 132 patients (80 men, 52 women, median age 68 years) with acute anterior circulation large vessel occlusive stroke receiving endovascular treatment were retrospectively analyzed at Jinling Hospital from October 2014 to September 2019. Patients were divided into two groups based on the occurrence of ENI, which was defined as either an improvement of NIHSS score of ≥4 points, or an NIHSS score of 0 or 1 at 24 hours after endovascular treatment. The rank sum test, Chi square test, and other methods were used to compare differences in baseline characteristics between the two groups. Logistic regression analysis was used to investigate independent predictors of postoperative ENI. Receiver operating characteristic curve analysis used to assess the capacity of NWU to predict ENI.Results:Of the 132 patients in the study, ENI occurred in 47 and did not occur in 85. In multivariate logistic regression analysis age [odds ratio ( OR)=0.940, 95% confidence interval ( CI) 0.903-0.979, P=0.003], time from stroke onset to puncture ( OR=0.995, 95% CI 0.991-0.999, P=0.025), time from puncture to recanalization/end of operation ( OR=0.985, 95% CI 0.974-0.996, P=0.007), NWU ( OR=0.762, 95% CI 0.620-0.937, P=0.010), and mTICI ( OR=1.644, 95% CI 1.043-2.590, P=0.032) were predictive factors for ENI. Receiver operating characteristic curve analysis indicated that NWU could effectively predict ENI (area under the curve=0.642, 95% CI 0.543-0.741, P=0.007), and prediction accuracy was improved when it was combined with other clinical parameters. Conclusion:NWU is an independent predictor of ENI in patients with acute anterior circulation large vessel occlusive stroke undergoing endovascular treatment.
