The incidence and metabolic profiles of adrenal incidentalomas in patients with diabetes
10.3760/cma.j.cn311282-20230221-00082
- VernacularTitle:糖尿病患者肾上腺意外瘤患病率及其代谢特征
- Author:
Yingning LIU
1
;
Xiantong ZOU
;
Wei ZHAO
;
Xun YAO
;
Lexuan WANG
;
Lingli ZHOU
;
Rui ZHANG
;
Yingying LUO
;
Meng LI
;
Xiuying ZHANG
;
Yu ZHU
;
Xiaoling CAI
;
Xianghai ZHOU
;
Xueyao HAN
;
Linong JI
Author Information
1. 北京大学人民医院内分泌与代谢科，北京 100044
- Keywords:
Adrenal incidentalomas;
Diabetes mellitus;
Computed tomography;
Hypertension;
Metabolic disorder
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(3):192-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the incidence of adrenal incidentalomas(AIs) in patients with diabetes mellitus and the metabolism profiles.Methods:A total of 615 hospitalized patients with diabetes mellitus in the Department of Endocrinology and Metabolism of Peking University People′s Hospital from March 2020 to May 2021 were retrospectively included in this study. AIs were screened by unenhanced chest computed tomography(CT) retrospectively and subsequently confirmed by multiplanar reconstruction. Participants′ physical indicators, metabolic profiles, and adrenal function parameters were collected. Unpaired t test, Mann-Whitney U test, and Chi-Square test were adopted to compare the metabolism profiles between diabetes mellitus patients with or without AIs. Regression models were used to estimate the correlations between AIs and the metabolism profiles such as blood glucose, blood lipids, blood pressure, and the adrenal function parameters.Results:Twenty-seven out of 615 participants were detected with AIs(4.4%). Patients with AIs had higher body mass index, waist circumference, and hip circumference than patients without AIs [(29.4±5.1)kg/m 2vs(26.8±3.8)kg/m 2,P=0.018; (102.3±11.7)cm vs(95.8±10.3)cm, P=0.002; (107.3±10.1)cm vs(101.4±7.6)cm, P=0.008]. The levels of serum uric acid and urinary albumin/creatinine ratio were also significantly increased in patients with AIs [(409.6±118.1)μmol/L vs(357.4±100.6)μmol/L, P=0.009; 21.25(7.49, 180.24)mg/g vs 8.60(4.71, 34.56)mg/g, P=0.010]. Besides, individuals with AIs were also associated with a higher risk of co-existing hypertension( P=0.045). Conclusion:The incidence of AIs in patients with diabetes is 4.4%. The presence of AIs in patients with diabetes may associated with increased risk of obesity and hypertension.
