Interleukin-6 mediates the association of low density lipoprotein-cholesterol with thyroid associated ophthalmopathy
10.3760/cma.j.cn311282-20230208-00062
- VernacularTitle:白细胞介素6在低密度脂蛋白胆固醇与甲状腺相关性眼病关联中发挥中介效应
- Author:
Shanshan WANG
1
;
Mingwei SHAO
;
Feng GUO
;
Wei ZHANG
;
Tian GAN
;
Ping LIU
;
Xiaotong WANG
;
Xiyuan ZHANG
;
Gaoyang FAN
;
Zirui ZHAO
;
Guijun QIN
Author Information
1. 郑州大学第一附属医院内分泌科，郑州 450052
- Keywords:
Thyroid associated ophthalmopathy;
Inflammatory factors;
Low density lipoprotein-cholesterol;
Mediating effect
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(12):1050-1055
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mediating effect of inflammatory factors in the association between low density lipoprotein-cholesterol(LDL-C) and thyroid associated ophthalmopathy(TAO).Methods:This study was a prospective study, which icluded a total of 86 patients with Graves′ disease who attended the Department of Endocrinology of the First Affiliated Hospital of Zhengzhou University from January 2021 to June 2022. Among them, there were 56 patients with Graves′ disease accompanied by TAO, including 30 cases in the inactive group and 26 in the active group. Additionally, there were 30 cases having Graves′ disease alone. The relationship between LDL-C, inflammatory factors, and the onset and activity of TAO were analyzed using binary logistic regression. Mediation analysis was used to explore the mediating effect of inflammatory factors in the association between LDL-C and TAO onset and activity.Results:Interleukin(IL) -6 was a potential mediator that linking the association between LDL-C and TAO onset: LDL-C had a direct effect on TAO(Total effect value=0.274, 95% CI 0.161-0.386), while IL-6(mediated effect=0.067, 95% CI 0.011-0.123) and IL-17(mediated effect=0.042, 95% CI 0.007-0.077) partially mediated the effect of LDL-C on TAO, accounting for 24.45% and 15.33% of the total effect, respectively. IL-6 was a potential mediator of the association between LDL-C and TAO activity: LDL-C had a direct effect on TAO activity(Total effect value=0.320, 95% CI 0.204-0.435), and IL-6(mediated effect=0.103, 95% CI 0.021-0.185) partially mediated the effect of LDL-C on TAO activity, with a mediation effect of 32.19%. Conclusion:IL-6 plays a partiall mediating role in the association of LDL-C with TAO onset and activity.
