Establishment and evaluation of a predicative model in diagnosing unilateral primary aldosteronism
10.3760/cma.j.cn311282-20230325-00132
- VernacularTitle:单侧性原发性醛固酮增多症的预测模型建立及价值评估
- Author:
Yangjie ZENG
1
;
Fan YANG
;
Yijie WANG
;
Zhaoyang TIAN
;
Menglian LI
;
Ping LI
;
Dalong ZHU
Author Information
1. 中国医学科学院北京协和医学院，南京鼓楼医院内分泌科 210008
- Keywords:
Primary aldosteronism;
Adrenal venous sampling;
Computed tomography;
Model
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(10):870-875
- CountryChina
- Language:Chinese
-
Abstract:
Primary aldosteronism(PA) is a common cause of secondary hypertension, with adrenal vein sampling(AVS)being the gold standard for etiological typing diagnosis. This retrospective study analyzed data from patients diagnosed with PA who underwent AVS or unilateral adrenalectomy at Nanjing Drum Tower Hospital′s Endocrinology Department from July 2018 to August 2021. Using multivariate logistic regression analysis, factors associated with unilateral aldosterone hypersecretion were identified. Based on these factors, a predictive model for diagnosing unilateral primary aldosteronism(UPA)was established: age <40 years, plasma aldosterone concentration(PAC)>15 ng/dL, adrenal CT indicating an unilateral typical adenoma, and spontaneous hypokalemia. This predictive model could help 14% of PA patients avoid unnecessary AVS procedures.
