Metabolic syndrome and early renal function injury of chronic kidney disease in elderly: A retrospective cohort study in Yunnan Province
10.3760/cma.j.cn311282-20220809-00471
- VernacularTitle:基于回顾性队列探索云南省老年人代谢综合征与慢性肾脏病早期肾脏损伤联系
- Author:
Ruifen LI
1
;
Yanmei ZHANG
;
Linyu WEI
;
Jianhua MA
;
Xueyan GU
;
Jun BAI
;
Peng LI
;
Wanyan CHEN
;
Huimin ZHAO
;
Li ZHANG
;
Li SU
Author Information
1. 兰州大学公共卫生学院儿少卫生与妇幼保健研究所，兰州 730000
- Keywords:
Metabolic syndrome;
Chronic kidney disease;
Retrospective cohort study;
Elderly
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(9):765-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between metabolic syndrome and the risk of early renal function injury in chronic kidney disease(CKD) in the elderly.Methods:A retrospective cohort was established based on health check-up data of 4 495 elderly residents in Mengzi City, Yunnan Province from January 2016 to December 2018. The medial history, living habits, and related physical examination information were collected. Cox hazard regression model was used to explore the association between metabolic syndrome, along with its components, and the early renal function injury in CKD. Results:The median age of the elderly was 71.00(67.00, 75.00) years, with metabolic syndrome detection rate of 21.98%. Early renal function injury of CKD developed in 1 300(28.92%) subjects during the follow-up. Univariate Cox regression showed that the number of metabolic syndrome components was associated with the risk of early kidney development in CKD. The HRs were 1.23 (95% CI 1.03-1.47, P=0.022) with 1 component, 1.54 (95% CI 1.28-1.84, P<0.001) with 2, and 1.38 (95% CI 1.14-1.67, P<0.001) with 3 or more. Multivariate Cox regression showed that elevated fasting triglycerides( HR=1.20, 95% CI 1.07-1.36, P=0.003) and lower high density lipoprotein-cholesterol(HDL-C; HR=1.25, 95% CI 1.09-1.43, P=0.002) were risk factors for early kidney injury in CKD, while doing some physical activity( HR=0.57, 95% CI 0.33-0.98, P=0.042), or on daily basis( HR=0.57, 95% CI 0.49-0.66, P<0.001) was a protective factor for early kidney injury in CKD. Conclusion:The abnormality of one or more metabolic components can significantly increase the risk of early kidney injury in the elderly with CKD. Elevated triglyceride and decreased HDL-C may be the risk factors.
