Expression of cancer-associated fibroblasts in thyroid cancer and the clinical relevance: A preliminary study
10.3760/cma.j.cn311282-20221031-00602
- VernacularTitle:癌相关成纤维细胞在甲状腺癌中的表达及临床相关性初步研究
- Author:
Li ZHU
1
;
Xuemei ZHANG
;
Guiming ZHOU
;
Dan WANG
;
Yujie ZHANG
;
Weiming WU
;
Shuhan ZHANG
;
Zhaowei MENG
Author Information
1. 天津医科大学总医院超声科，天津 300052
- Keywords:
Papillary thyroid cancer;
Cancer-associated fibroblasts;
Extrathyroid invasion;
Lymph node metastasis;
Multi-focality;
Risk factor
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(9):739-745
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of cancer-associated fibroblasts(CAFs) marker proteins in papillary thyroid carcinoma(PTC) using immunohistochemistry and explore their correlation with clinicopathological characteristics.Methods:The clinicopathological data of 90 PTC patients at Tianjin Medical University General Hospital from December 2019 to January 2021 were retrospectively analyzed. Surgical pathological cancer tissue samples were selected for immunohistochemical staining, and control group tissues were obtained from normal thyroid tissue adjacent to the tumor lesion. Four CAFs marker proteins, including fibroblast-activated protein(FAP), α-smooth muscle actin(α-SMA), Vimentin, and platelet-derived growth factor receptor-α(PDGFR-α), were stained and scored, followed by statistical analysis.Results:The immunoreactivity score of the CAFs marker proteins were correlated with extrathyroid invasion, lymph node metastasis, and multi-focality of PTC. FAP and α-SMA demonstrated better performance in this regard. Multivariate logistic regression analysis and receiver operating characteristic(ROC) curve analysis showed that high immunoreactivity scores of FAP and α-SMA were risk factors for poor clinical pathological features, with good predictive sensitivity and accuracy.Conclusion:Strong expression of CAFs was the risk factor for extrathyroid invasion, lymph node metastasis, and mutli-focality of PTC. FAP has the highest clinical value compared with other CAFs marker proteins.
