Interaction between remimazolam and propofol for sedation during hysteroscopy
10.3760/cma.j.cn131073.20231020.00216
- VernacularTitle:瑞马唑仑和丙泊酚用于宫腔镜检查术镇静效应的相互作用
- Author:
Leting JI
1
;
Peipei HAO
;
Ning DING
;
Ningning DU
;
Guangchao ZHU
;
Changsheng LI
;
Xiaoyong WEI
Author Information
1. 郑州大学第三附属医院麻醉科，郑州 450052
- Keywords:
Benzodiazepines;
Propofol;
Hysteroscopy;
Hypnotics and sedatives;
Drug interactions
- From:
Chinese Journal of Anesthesiology
2024;44(2):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the interaction between remimazolam and propofol for sedation during hysteroscopy.Methods:American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 20-45 yr, with body mass index of 18-28 kg/m 2, scheduled for elective hysteroscopy, were included. The test was conducted in two steps. Up-and-down sequential allocation was used to determine the median effective dose (ED 50) of remimazolam (group A) and propofol (group B). The ED 50 obtained in A and B groups were then used as the standard to determine the combination regimen in group C (0.25×ED 50 of remimazolam+ 0.75×ED 50 of propofol as the initial dose), in group D (0.5×ED 50 of remimazolam+ 0.5×ED 50 of propofol as the initial dose), and in group E (0.75×ED 50 of remimazolam+ 0.25×ED 50 of propofol as the initial dose). Up-and-down sequential allocation was used to determine the ED 50 of propofol when propofol and remimazolam were combined in C, D and E groups. The interaction between the sedative effects of two drugs was analyzed using the isobolographic analysis method, and the interaction coefficient and synergistic dose ratio of two drugs were calculated. Results:The ED 50 of remimazolam was 0.180 mg/kg in group A, and the ED 50 of propofol was 1.167 mg/kg in group B. The results of isobolographic analysis showed that remimazolam and propofol had a synergistic effect. When remimazolam 0.045, 0.090 and 0.135 mg/kg were combined with propofol 0.546, 0.288 and 0.160 mg/kg, the interaction coefficients were 1.393, 1.339 and 1.127 respectively. The synergistic dosage ratio of remimazolam and propofol was 1.0∶(3.2 to 12.0). Conclusions:Remimazolam and propofol have a synergistic effect on sedation when used for hysteroscopy, and the dose ratio is 1.0∶(3.2-12.0).
