Pharmacodynamics of remimazolam tosilate inducing loss of consciousness when combined with sufentanil in children
10.3760/cma.j.cn131073.20230828.00113
- VernacularTitle:复合舒芬太尼时甲苯磺酸瑞马唑仑用于儿童意识消失的药效学
- Author:
Shaochao WANG
1
;
Lei WANG
;
Chao WANG
;
Wen ZHAO
;
Yunlei ZAN
;
Quande LI
;
Xiaoli LIN
Author Information
1. 山东大学附属儿童医院(济南市儿童医院)麻醉科，济南 250022
- Keywords:
Benzodiazepines;
Sufentanil;
Children;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(1):63-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the pharmacodynamics of remimazolam tosilate inducing loss of consciousness (LOC) when combined with sufentanil in children.Methods:American Society of Anesthesiologists Physical Status classificationⅠ or Ⅱ pediatric patients of either sex, aged 3-6 yr, undergoing electronic bronchoscopy, were included in this study. ECG monitoring was carried out in all children after admission, sufentanil 0.1 μg/kg was intravenously injected slowly, and 3 min later remidazolam tosilate was intravenously injected. The dose of remimazolam tosilate was determined by the modified Dixon′s up-and-down sequential experiment, and the initial dose of remimazolam tosilate was 0.30 mg/kg. The dose of remimazolam tosilate in the next child was determined according to the the loss of consciousness, and the successive dose gradient was 0.05 mg/kg. Loss of eyelash reflex and Modified Observer′s Assessment of Alertness/Sedation Scale score reaching 0 and the occurrence of 8 crossover points where consciousness transitioned from non-disappearance to disappearance after 1 min of remimazolam tosilate injection were considered to be signs of LOC. The median effective dose (ED 50), 95% effective dose (ED 95), and their 95% confidence interval ( CI) of remimazolam tosilate inducing LOC were calculated using probit method. Results:When combined with sufentanil, the ED 50 and 95% CI of remimazolam tosilate inducing loss of consciousness were 0.461 (0.429-0.493) mg/kg, and the ED 95 and 95% CI were 0.515 (0.487-0.689) mg/kg. Conclusions:When combined with sufentanil, the ED 50 of remimazolam tosilate inducing LOC is 0.461 mg/kg and the ED 95 is 0.515 mg/kg in children.
