Effect of wrist-ankle acupuncture on pharmacodynamics of remimazolam for loss of consciousness in patients of different genders and ages undergoing painless gastroscopy
10.3760/cma.j.cn131073.20230326.01220
- VernacularTitle:腕踝针对瑞马唑仑用于不同性别年龄无痛胃镜检查术患者意识消失药效学的影响
- Author:
Lili KONG
1
;
Na ZHOU
;
Jianan HOU
;
Jing YUAN
;
Qinxian WANG
;
Yanli LI
;
Yanhong LI
;
Wei HAO
Author Information
1. 河北中医学院第一附属医院麻醉科 河北省中西医结合胃肠病研究重点实验室，石家庄 050011
- Keywords:
Wrist ankle acupuncture therapy;
Benzodiazepines;
Gastroscopy;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2023;43(12):1507-1509
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of wrist-ankle acupuncture on the pharmacodynamics of remimazolam for loss of consciousness in the patients of different genders and ages undergoing painless gastroscopy.Methods:American Society of Anesthesiologists Physical Status classificationⅠor Ⅱ patients, undergoing elective painless gastroscopy, were divided into 4 groups according to gender and age: agedmale (age≥65 yr) group (group AM), agedfemale (age≥65 yr) group (group AF), young male (18 yr≤age <65 yr) group (group YM), and young female (18 yr≤age <65 yr) group (group YF). After 10 min of wrist-ankle acupuncture on 1st and 2nd areas of the bilateralupper limbs of the patient, modified Dixon′s up-and-down sequential experiment was used for the test.The initial dose of intravenous remimazolam was 0.20 mg/kg. Each time the dose increased/decreased by 0.05 mg/kg. If the patient lost consciousness, the next patient received a lower dose of remimazolam, otherwise a higher dose was given in the next patient. Loss of consciousness was defined as MOAA/S score was 0 or 1, and the process was repeated until 7 turning points appeared.The median effective dose (ED 50)and 95% confidence interval of remimazolam were calculated by probit method. Results:The ED 50 and 95% confidence interval of remimazolam were 0.296(0.233-0.376), 0.319(0.262-0.388), 0.323(0.278-0.375) and 0.344(0.285-0.415)mg/kg in AM, AF, YM and YF groups, respectively. There was no significant difference in ED 50 among the four groups ( P>0.05). Conclusions:Under the action of wrist-ankle acupuncture, the pharmacodynamics of remazolam is comparable when used for the patients of different genders and ages undergoing painless gastroscopy.
