Safety and efficacy of ciprofol and propofol for gynecologic surgery with general anesthesia: a meta-analysis
10.3760/cma.j.cn131073.20230524.00913
- VernacularTitle:环泊酚与丙泊酚用于妇科全身麻醉手术的安全性与有效性：meta分析
- Author:
Yunpeng XU
1
;
Yufang LENG
;
Xuena HAN
;
Shuting CHANG
;
Mingming CHEN
;
Hong GUO
;
Jian LIU
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Keywords:
Hypnotics and sedatives;
Anesthesia, general;
Meta-analysis
- From:
Chinese Journal of Anesthesiology
2023;43(9):1087-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the safety and efficacy of ciprofol and propofol for gynecological surgeries with general anesthesia through a meta-analysis.Methods:Electronic databases including PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure, Wanfang Data, China Biomedical Literature Database, and China Science and Technology Journal Database were searched for randomized controlled trials comparing the safety and efficacy of ciprofol and propofol in gynecological surgeries with general anesthesia from inception to May 2023. Meta-analysis was performed using Revman 5.4 software.Results:Six randomized controlled trials were included, involving 741 patients, of which 371 received ciprofol and 370 received propofol. Compared with propofol group, the emergence time was significantly prolonged, the difference in mean arterial blood pressure, systolic blood pressure and diastolic blood pressure before and after anesthesia induction was decreased, and the incidence of injection pain, respiratory depression, body movement and hypotension was decreased in ciprofol group ( P<0.05). There were no significant differences between the two groups in terms of time of successful anesthesia induction, difference in BIS values and heart rate before and after anesthesia induction, and incidence of tachycardia, bradycardia and hypertension ( P>0.05). Conclusions:Ciprofol is comparable to propofol in terms of efficacy and has better safety than propofol when used in gynecologic surgeries with general anesthesia.
