Effect of remimazolam on hemodynamics when used for anesthesia induction in patients undergoing coronary artery bypass grafting
10.3760/cma.j.cn131073.20230321.00904
- VernacularTitle:瑞马唑仑用于冠状动脉旁路移植术患者麻醉诱导对血流动力学的影响
- Author:
Ni ZENG
1
;
Feng XIAO
;
Ruping DAI
;
Yanling ZHANG
Author Information
1. 中南大学湘雅二医院麻醉科，长沙 410011
- Keywords:
Benzodiazepines;
Coronary artery bypass;
Hemodynamics
- From:
Chinese Journal of Anesthesiology
2023;43(9):1042-1046
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of remimazolam on hemodynamics when used for anesthesia induction in patients undergoing coronary artery bypass grafting (CABG).Methods:Sixty patients of either sex, aged 18-64 yr, of American Society of Anesthesiologists Physical Status classification Ⅱ-Ⅲ, with ejection fraction>35%, cardiac index (CI) >2.0 L·min -1·m -2 and body mass index <28 kg/m 2, undergoing CABG under general anesthesia, were divided into 2 groups ( n=30 each)using a random number table method: remazolam group (group R) and midazolam group (group M). Group R received intravenous remimazolam 0.08 mg/kg, and group M received intravenous midazolam 0.05 mg/kg, and both groups used sufentanil, etomidate, and rocuronium bromide for anesthesia induction to maintain the BIS value at 40-65. Before anesthesia induction, at 1-2 min after intravenous injection of remimazolam/midazolam-sufantanil-etomidate, immediately before tracheal incubation, at 30 s-15 min after tracheal intubation, and immediately before skin incision, blood pressure, heart rate, mean arterial pressure, CI, stroke volume index, systemic vascular resistance index, and left heart systolic index were measured, and vasoactive drugs were used to maintain the stability of vital signs and to record the cardiovascular events. Results:Compared with group M, the incidence of hypotension and usage rate of vasoactive drugs were significantly decreased, and the incidence of decrease in CI and stroke volume index by more than 20% and changes in left heart systolic index were decreased in group R( P<0.05). Conclusions:Remimazolam can reduce the disturbance of hemodynamics to a certain extent when used for anesthesia induction as compared with midazolam in patients undergoing CABG.
