Stem cell stemness mechanisms and their role in the management of prostate cancer

VernacularTitle:干细胞的干性机制及其在前列腺癌诊疗中的研究进展
Author: Zhiyong TAN ¹ ; Shi FU ; Jieming ZUO ; Yinglong HUANG ; Haifeng WANG ; Jiansong WANG
Author Information

1. 昆明医科大学第二附属医院泌尿外科，昆明　650101
Keywords: Prostate cancer; Cancer stem cells; Stemness maintenance mechanism; Diagnosis and treatment
From: Chinese Journal of Urology 2023;44(12):957-960
CountryChina
Language:Chinese
Abstract: Prostate cancer is one of the most frequent malignancies of the urological tract. Surgery, radiotherapy, and immunotherapy are the main treatment methods for prostate cancer, which often lead to unsatisfactory outcomes due to the obvious heterogeneity of the tumor. Recently, poorly differentiated, self-renewing cancer initiation sites and treatment-resistant cancer stem cells (CSC) have become a hot topic in prostate cancer research. Targeting prostate cancer stem cells is a novel and promising therapy. In this article, we review the mechanism of stemness maintenance of CSC, its impact on the tumor microenvironment, and the related research progress in prostate cancer treatment, providing a theoretical basis for the targeted therapy of prostate cancer stem cells.