Application of single-cell sequencing technology in bladder cancer research
10.3760/cma.j.cn112330-20220420-00219
- VernacularTitle:单细胞测序技术在膀胱癌研究中的应用
- Author:
Wei WANG
1
;
Zhenduo SHI
;
Conghui HAN
Author Information
1. 徐州市中心医院泌尿外科 东南大学医学院附属徐州医院 徐州医科大学徐州临床学院，徐州 221009
- Keywords:
Single cell sequencing;
Bladder cancer;
Heterogeneity;
Tumor microenvironment
- From:
Chinese Journal of Urology
2023;44(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Single-cell sequencing is a new technology for high-throughput sequencing analysis of the genome, transcriptome, and epigenome at the single-cell level. Currently, single-cell sequencing technology has been widely used in bladder cancer research, opening up new ways to understand the biology of subtle bladder tumors by identifying different cell subpopulations, immune microenvironment, and single-cell technology is expected to make important changes in bladder diagnosis and treatment by identifying new biomarkers and using targeted therapies. This paper discussed the application of single-cell sequencing in bladder cancer research and clinical practice by summarizing recent advances in heterogeneous cell subpopulations, developmental patterns, and immune microenvironment and drug resistance in bladder cancer.
