Association between the visceral adiposity index and cognitive decline in community-dwelling elderly residents
10.3760/cma.j.issn.0254-9026.2024.03.016
- VernacularTitle:城市社区老年居民内脏脂肪指数与认知功能下降的关联性研究
- Author:
Yang HE
1
;
Xinyu XIE
;
Wei SHEN
;
Weiwei ZHANG
;
Yuhao GE
;
Dongmei KANG
Author Information
1. 中国科学技术大学附属第一医院（安徽省立医院）老年医学科，合肥 230000
- Keywords:
Obesity;
Insulin resistance;
Cognition;
Visceral fat
- From:
Chinese Journal of Geriatrics
2024;43(3):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the visceral adiposity index(VAI) and cognitive decline.Methods:A cross-sectional study was conducted.Between October 2020 and March 2023, 483 elderly residents living in communities in Hefei were recruited and divided into four groups based on VAI scores, Q1(VAI ≤ 1.14), Q2(VAI>1.15 and ≤1.85), Q3(VAI>1.86 and ≤2.81) and Q4(VAI>2.82).General cognitive function was assessed by(MMSE)and(MoCA).Attention and working memory were tested by forward and backward digit span tasks.Logistic regression was utilized to analyze the relationship between different VAI scores and insulin resistance.The correlation between different VAI scores and cognitive function domains was analyzed by partial correlation.Results:The values of BMI, fasting plasma glucose, fasting insulin, HbA1c, high-sensitivity C-reactive protein, HOMA-IR and HOMA-β increased with increasing VAI scores(all P<0.01).VAI was significantly correlated with insulin sensitivity after adjusting for confounding factors including sex.The risk of insulin resistance in Q4 was 7.40 times that in Q1( OR=7.40, 95% CI: 4.30-12.74, P<0.05).In addition, the correlation coefficients between VAI and forward digital span and between VAI and backward digital span were -0.116 and -0.105, respectively(both P<0.05), but there was no correlation between VAI and MMSE or MoCA. Conclusions:VAI is closely related to insulin resistance and also associated with early cognitive decline in elderly people with visceral obesity.
