Clinical significance of tumor budding as a marker for predicting distant metastasis after radical gastrectomy in elderly patients
10.3760/cma.j.issn.0254-9026.2024.03.008
- VernacularTitle:肿瘤出芽作为预测老年患者胃癌根治术后远处器官转移标志物的临床意义探讨
- Author:
Yu JIE
1
;
Pei WANG
;
Lin YAO
;
Yimeng SUN
;
Wei XU
;
Yue QIU
;
Dapeng JIANG
;
Xiaoyan WANG
;
Yu FAN
Author Information
1. 江苏大学附属人民医院肿瘤研究所，镇江 212002
- Keywords:
Stomach Neoplasms;
Neoplasm metastasis;
Tumor markers, biological;
Tumor budding
- From:
Chinese Journal of Geriatrics
2024;43(3):311-316
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of tumor budding as an indicator of postoperative distant organ metastasis after radical gastrectomy in elderly patients diagnosed with gastric cancer.Methods:The clinical and pathological data of 124 elderly patients who experienced metastasis after undergoing radical gastrectomy were retrospectively analyzed.The analysis was conducted from March 2015 to June 2022, focusing on the clinicopathological factors that influenced the occurrence of postoperative distant metastasis in these patients.Tumor budding in gastric cancer tissues was assessed using hematoxylin-eosin staining, and its clinical significance was analyzed.Results:The tumor budding grade of gastric cancer tissues showed a significant correlation with vascular invasion( χ2=6.731, P=0.009), the number of lymph node metastases( rs=0.481, P<0.001), and the time of distant metastasis( rs=-0.450, P<0.001).In the univariate analysis, factors such as tumor budding grade, tumor size, vascular invasion, postoperative chemotherapy, cancerous nodule, preoperative serum carbohydrate antigen 125, and the number of lymph node metastases were found to influence distant metastasis-free survival after radical gastrectomy in elderly patients(all P<0.05).The multifactorial analysis also indicated that tumour outgrowth grade was an important independent prognostic factor for postoperative distant metastasis in elderly gastric cancer patients( HR=3.731, P<0.001). Conclusions:The findings of this study indicate that tumor budding may serve as a potential marker for predicting distant organ metastasis in elderly patients who have undergone radical gastrectomy.This discovery holds significant clinical implications.
