Research progress on the correlation between weight loss and ghrelin, leptin and hypoxic environment in patients with Parkinson's disease

VernacularTitle:帕金森病患者体重减轻与胃饥饿素和瘦素以及低氧环境的相关性研究进展
Author: Jiangang LIU ¹ ; Aiqin ZHU
Author Information

1. 青海大学研究生院，西宁　810000
Keywords: Parkinson disease; Weight loss; Leptin; Ghrelin
From: Chinese Journal of Geriatrics 2024;43(2):246-250
CountryChina
Language:Chinese
Abstract: Weight loss is a prevalent non-motor symptom of Parkinson's disease(PD), often appearing several years before motor symptoms and continuing throughout the course of the disease.The cause of weight loss in PD may be linked to an imbalance in energy and neuroendocrine function.Ghrelin and leptin are thought to be significant factors in the weight loss experienced by those with PD.Obstructive sleep apnea hypopnea syndrome may independently increase the risk of PD and significantly impact the cognitive and motor functions, as well as other non-motor symptoms, of PD patients.Research has shown that a hypoxic environment can enhance the expression and aggregation of the pathogenic protein α-synuclein.This suggests that hypoxic stress and intermittent hypoxia may be contributing factors to the development of PD.This article examines the correlation between weight loss in patients with Parkinson's disease and the hormones ghrelin and leptin, as well as the impact of a hypoxic environment on these hormones.