Changes of the vaginal environment in genitourinary syndrome of menopause and progress on the use of mesenchymal stem cells as an intervention

VernacularTitle:绝经泌尿生殖综合征的阴道环境变化及间充质干细胞在其中的应用进展
Author: Xuan JI ¹ ; Yunlang CAI
Author Information

1. 东南大学医学院，南京　210009
Keywords: Perimenopause; Genitourinary syndrome of menopause; Mesenchymal stem cells
From: Chinese Journal of Geriatrics 2024;43(1):92-97
CountryChina
Language:Chinese
Abstract: Due to decreased estrogen levels in patients with genitourinary syndrome of menopause(GSM), changes occur in the vaginal environment, including changes in vaginal tissue structure, the vaginal microbiota and vaginal mucosal immunity, resulting in a series of symptoms and signs.To develop effective treatment methods for GSM, it is necessary to fully understand potential molecular mechanisms underlying these changes.Mesenchymal stem cells(MSCs)can promote the regeneration of aging tissues, secrete growth factors, and have excellent immune regulation and anti-inflammatory capabilities.They are a powerful treatment option for reproductive aging.Therefore, it is essential to understand changes of the vaginal environment in GSM patients and progress on the use of MSCs as an intervention, in order to gain insight into research on the treatment of GSM.