Research progress on the relationship between Alzheimer's disease and obstructive sleep apnea

VernacularTitle:阿尔茨海默病和阻塞性睡眠呼吸暂停的关系
Author: Dongmei LUO ¹ ; Tenghong LIAN ; Peng GUO ; Wei ZHANG
Author Information

1. 首都医科大学附属北京天坛医院神经病学中心，北京　100070
Keywords: Alzheimer's disease; Obstructive sleep apnea
From: Chinese Journal of Geriatrics 2024;43(1):1-7
CountryChina
Language:Chinese
Abstract: Alzheimer's disease(AD)is the most common cognitive disorder in the elderly and manifests primarily as progressive cognitive function decline, neuropsychiatric symptoms and multiple functional impairments.Obstructive sleep apnea(OSA)is a common type of respiratory disorder.Studies have found that AD and OSA are connected in many ways, including the risk of developing these diseases, biomarkers and neuroimaging features.These connections may result from a variety of mechanisms, such as neuropathological protein deposition, exacerbated immune-mediated inflammation, oxidative stress abnormalities, impaired mitochondrial function, and disturbed neurotransmitter systems, among others.This article reviewed the relationship between AD and OSA, the mechanisms linking them and their treatment.