A single-center retrospective analysis of autologous hematopoietic stem cell transplantation for the treatment of multiple myeloma in the elderly
10.3760/cma.j.issn.0254-9026.2023.12.006
- VernacularTitle:自体造血干细胞移植治疗老年多发性骨髓瘤的单中心回顾性分析
- Author:
Jing WANG
1
;
Xiaolan SHI
;
Song JIN
;
Lingzhi YAN
;
Xiao MA
;
Chengcheng FU
;
Depei WU
;
Jingjing SHANG
Author Information
1. 苏州弘慈血液病医院血液科，苏州 215128
- Keywords:
Multiple myeloma;
Hematopoietic stem cell transplantation;
Time of implantation
- From:
Chinese Journal of Geriatrics
2023;42(12):1425-1429
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of autologous hematopoietic stem cell transplantation(auto-HSCT)for the treatment of multiple myeloma(MM)in elderly patients aged over 65 years.Methods:In this retrospective analysis, the efficacy and safety of auto-HSCT for the treatment of MM was examined in 28 patients aged >65 years diagnosed and treated at Soochow Hopes Hematology Hospital between March 1, 2020 and October 31, 2022.The functions of the major organs of these patients were evaluated before transplantation.Results:The 28 patients had a median age of 67(66-72)at the time of transplantation, a median number of 2.985 × 10 6/kg(2.036-9.5 × 10 6/kg)of collected CD34+ hematopoietic stem cells, and a median number of 2(1-3)days of collection.The median time to neutrophil implantation after hematopoietic stem cell transfusion was 10(9-14)days, and the median platelet implantation time was 11(10-29)days.The median follow-up time was 25 months, but the median progression-free survival time was not reached.The 1-year PFS rate was 89.3% and 2-year PFS rate was 76.3%, with 2 patients' starting point of PFS set at the time of pre-transplantation re-induction therapy because needed salvage auto-HSCT.The overall survival time was not reached, the 1-year overall survival rate was 100.0%, and the 2-year overall survival rate was 90.5%. Conclusions:Auto-HSCT is a safe and effective treatment for elderly MM patients aged over 65 years after screening and assessment.
