Mechanism research progress on the microglia evolution in aging
10.3760/cma.j.issn.0254-9026.2023.11.018
- VernacularTitle:小胶质细胞演变致衰老相关机制研究进展
- Author:
Zhenjiao YANG
1
;
Yongsheng ZHANG
;
Xuefei BAO
;
Xiaoyan HE
;
Xiuhong LU
;
Guoliang CHEN
Author Information
1. 上海健康医学院附属嘉定中心医院上海市分子影像学重点实验室，上海 201318
- Keywords:
Aging;
Microglial cell;
Neuron degeneration diseases;
Lipid droplet accumulating microglia
- From:
Chinese Journal of Geriatrics
2023;42(11):1373-1379
- CountryChina
- Language:Chinese
-
Abstract:
The results clearly demonstrate the close relationship between the evolution of microglia and the mechanisms underlying aging.Monitoring the status of microglia can greatly contribute to diagnosing aging and related neurodegenerative diseases.Furthermore, protecting the function of microglia is a viable strategy for slowing down brain aging and preserving brain function.This approach offers a feasible intervention strategy for tackling aging and degenerative diseases.This paper provides a comprehensive summary of the changes that occur in microglia during the aging process.It also examines the impact of these changes in microglia function on neurons and astrocytes in the brain.
