Correlation study of serum creatinine/cystatin C and sarcopenia
10.3760/cma.j.issn.0254-9026.2023.09.011
- VernacularTitle:血清肌酐与胱抑素C比值与肌少症的相关性
- Author:
Sihui MA
1
;
Xiangyu ZHANG
;
Lin CHEN
Author Information
1. 中南大学湘雅二医院老年医学科 湖南省老年综合征临床医学研究中心，长沙 410011
- Keywords:
Biological markers;
Hand strength;
Sarcopenia;
Serum creatinine/cystatin C
- From:
Chinese Journal of Geriatrics
2023;42(9):1083-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum creatinine/cystatin C(Scr/CysC)ratio and sarcopenia, and search for serum markers specific to sarcopenia.Methods:A retrospective case-control study of 142 hospitalized patients in the Department of Geriatrics, Xiangya Second Hospital, Central South University from November 2020 to February 2022 were collected, including 43 sarcopenia cases and 99 non sarcopenia cases.The correlation between Scr/CysC ratio and sarcopenia was analyzed and explored.Results:The Scr/CysC ratio of 71.5±12.5 in the sarcopenia group was significantly lower than that of 81.9±15.8 in the non-sarcopenia group( t=3.823, P<0.001), and Scr/CysC was positively correlated with muscle mass and grip strength( r=0.52, 0.69, both P<0.001).The results of the analysis of receiver operating characteristic curves of the subjects showed that in male inpatients, the area under the curve(AUC)of the Scr/CysC ratio in the diagnosis of sarcopenia was 0.770(95% CI: 0.655 to 0.886, P<0.001), with a diagnostic reference value of 80.97, which gave a sensitivity of 72.2% and a specificity of 68.4%.In female inpatients the AUC was 0.621(95% CI: 0.474 to 0.768, P=0.099), with a diagnostic reference value of 65.20, giving a sensitivity of 77.8% and a specificity of 58.3%. Conclusions:The serum Scr/CysC ratio may be a serum marker for male sarcopenia patients, and sarcopenia may be considered when it is below 80.97; The diagnostic value in female sarcopenia needs further research.
