A preliminary study on the relationship between macrophage migration inhibitory factor, interleukin-6 and Periodontal disease, atherosclerosis in middle aged and old people
10.3760/cma.j.issn.0254-9026.2023.09.006
- VernacularTitle:中老年人巨噬细胞迁移抑制因子和白细胞介素-6与牙周炎及动脉粥样硬化相关性的研究
- Author:
Hong YANG
1
;
Xiaoxia WANG
;
Yifan YANG
;
Pei CAO
;
Qingxian LUAN
Author Information
1. 北京医院口腔科 国家老年医学中心，中国医学科学院老年医学研究院，北京 100730
- Keywords:
Periodontitis;
Atherosclerosis;
Macrophage migration-inhibitory factor;
Interleukin 6
- From:
Chinese Journal of Geriatrics
2023;42(9):1052-1056
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between macrophage migration inhibitory factor(MIF), Interleukin 6(IL-6), periodontal disease, and atherosclerosis in middle-aged and elderly individuals.Methods:This cross-sectional study enrolled 700 diabetic patients who were attending the endocrinology department of Beijing Hospital from January 2020 to December 2022.Out of these patients, 491 underwent a full-mouth periodontal examination.Among them, 106 were middle-aged and elderly.The study included 83 patients with complete data, aged between 45 and 70 years(mean age: 58.2±8.7 years).Among the included patients, 48 were male(57.8%)and 35 were female(42.2%).A questionnaire was administered to gather information about the patients, and serum levels of MIF and IL-6 were measured using enzyme-linked immunosorbent assay(ELISA).The relationship between serum MIF and IL-6 levels and periodontitis and atherosclerosis was evaluated through univariate and multifactorial analyses conducted on middle-aged and elderly individuals.Results:There were 66 cases(79.5%)in the periodontitis stage Ⅰ/Ⅱ group and 17 cases(20.5%)in the stage Ⅲ/Ⅳ group.The serum MIF levels in the two groups were(2, 312.5±795.0)ng/L and(2, 939.8±665.0)ng/L, respectively( P<0.01).Similarly, IL-6 levels were(3.5±3.0)ng/L and(6.7±6.1)ng/L in the two groups( P>0.05).The findings revealed that for each 1 ng/L increase in MIF serum levels, the risk of severe periodontitis and increased carotid intima-media thickness(cIMT)increased by 0.1%.Furthermore, for each 1 ng/L increase in serum MIF and IL-6 levels, the risk increased by 0.2% and 38.9% respectively.Serum MIF levels were found to be associated with atherosclerosis as well as with various factors related to periodontitis, including periodontal probing depth, bleeding index, clinical attachment level, periodontal probing depth≥4 mm sites, clinical attachment level≥5%, and bleeding index >2%(all P<0.05). Conclusions:This study investigates the correlation between MIF and IL-6 levels with Periodontal disease and Atherosclerosis in middle-aged and elderly individuals.
