A resting-state MRI-based study on the characteristics of degree centrality of local brain function in patients with levodopa-induced dyskinesias
10.3760/cma.j.issn.0254-9026.2023.09.003
- VernacularTitle:基于静息态磁共振对左旋多巴诱导的异动症患者的局部脑功能度中心度特征的研究
- Author:
Heng ZHANG
1
;
Xingyue CAO
;
Yongsheng YUAN
;
Min JI
;
Huimin SUN
;
Lina WANG
;
Caiting GAN
;
Kezhong ZHANG
Author Information
1. 南京医科大学第一附属医院神经内科，南京 210029
- Keywords:
Parkinson's disease;
Levodopa;
Dyskinesias;
Resting-state magnetic resonance imaging;
Degree centrality
- From:
Chinese Journal of Geriatrics
2023;42(9):1035-1040
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of regional brain functional centrality(DC)in patients with levodopa-induced dyskinesia(LID)and to explore the pathogenesis of LID.Methods:A total of 33 PD patients with LID(PD-LID), 41 PD patients without LID(PD-nLID)and 37 healthy controls from the First Affiliated Hospital of Nanjing Medical University were enrolled in this study.Differences in DC among the three groups were compared and the correlation between Z-DC values of the brain regions with differences and the scores of the involuntary movement scale(items 1-7)was analyzed.Results:Compared with Controls, PD-LID patients showed increased DC in the right amygdala(extending to the right globus pallidus)(MNI: x=30, y=-3, z=-18, t=4.00, P<0.05 after AlphaSim correction)and in the right postcentral gyrus(MNI: x=57, y=-9, z=39, t=-3.59; MNI: x=42, y=-33, z=57, t=-4.23, P<0.05 after AlphaSim correction)and reduced DC in the right superior parietal lobule(MNI: x=24, y=-51, z=72, t=-3.95, P<0.05 after AlphaSim correction).Compared with the PD-nLID group, the PD-LID group showed increased DC in the right globus pallidus(MNI: x=30, y=-12, z=-3, t=3.09, P<0.05 after AlphaSim correction).DC changes in the right globus pallidus were positively correlated with AIMS score( r=0.482, P=0.004). Conclusions:The enhancement of DC function in the right globus pallidus may be closely related to the onset and severity of LID.
