Advances in molecular mechanisms of Metformin against aging
10.3760/cma.j.issn.0254-9026.2023.08.022
- VernacularTitle:二甲双胍抗衰老分子机制的研究进展
- Author:
Hao WANG
1
;
Xiaoxuan NING
Author Information
1. 空军军医大学第一附属医院老年病科，西安 710032
- Keywords:
Metformin;
Aging;
Molecular biology;
Adaptor proteins, signal transduction;
Mitochondria
- From:
Chinese Journal of Geriatrics
2023;42(8):1001-1007
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a prevalent disease among the elderly population.Among the antidiabetic drugs, Metformin is the most commonly used, and has been found to have unique anti-aging effects through nutritional sensing regulation, maintenance of protein homeostasis, protection of mitochondrial function, alteration of intercellular communication, and telomere protection, among other mechanisms.The results of studies have shown that Metformin has significant anti-aging potential, thereby necessitating a thorough analysis and summary of its molecular mechanism and research progress in this regard.
