Value of TREM2 for early hematoma expansion in elderly patients with spontaneous cerebral hemorrhage
10.3969/j.issn.1009-0126.2024.03.016
- VernacularTitle:可溶性2型髓系细胞触发受体对老年自发性脑出血患者血肿早期扩大的评估价值
- Author:
Yu YUAN
1
;
Jie GAO
;
Mingyue LI
;
Kuan LIU
;
Xu LIU
Author Information
1. 063000 唐山市工人医院神经外二科
- Keywords:
cerebral hemorrhage;
hematoma;
soluble type 2 myeloid cell triggering receptor
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(3):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of baseline plasma soluble type 2 myeloid cell trigger receptors(sTREM2)in evaluation for early hematoma enlargement in elderly patients with spontan-eous cerebral hemorrhage(SCH).Methods Clinical data of 240 patients with acute SCH admitted to our hospital from January 2020 to August 2022 were collected and analyzed retrospectively.According to the expansion of the hematoma volume,they were divided into non-expansion group(172 cases)and expanded group(68 cases).Baseline head CT scanning was performed in all patients within 24 h of onset,clinical and imaging data were analyzed,and the volume of cerebral hematoma was calculated.Blood samples were collected immediately after admission and sTREM2 and galectin-3 levels were measured.Results Compared with the non-expansion group,the ex-panded group had larger cerebral hematoma volume,and increased levels of sTREM2,galectin-3,hs-CRP and TNF-a at admission(P＜0.01).Pearson correlation analysis showed that the expres-sion levels of sTREM2 and galectin-3 were positively correlated with cerebral hematoma at ad-mission(r=0.784,P=0.012;r=0.815,P=0.004).ROC curve analysis indicated that the sensi-tivity of combined serum sTREM2 and galectin-3 levels was significantly higher than that of sin-gle detection(85.59％vs 73.73％and 64.41％,P＜0.05),and the AUC value was 0.896(95％CI:0.741-0.932).Conclusion The baseline plasma level of sTREM2 is significantly increased in eld-erly SCH patients after early hematoma expansion.So,sTREM2 can be used as a risk marker for early expansion of hematoma,and its combined detection with galectin-3 shows higher diagnostic value.
