Efficacy of dronedarone combined with metoprolol on elderlv patients with atrial arrhythmia
10.3969/j.issn.1009-0126.2024.03.005
- VernacularTitle:决奈达隆联合美托洛尔应用于老年房性心律失常患者的疗效观察
- Author:
Yaoyao HU
1
;
Jia LIU
;
Xiang GU
;
Ye ZHU
Author Information
1. 225001 扬州大学临床医学院
- Keywords:
arrhythmias,cardiac;
metoprolol;
dronedarone;
anti-arrhythmia agents
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(3):258-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of dronedarone combined with low dose metoprol-ol in the treatment of atrial tachycardia.Methods A total of 175 elderly patients with atrial tachy-cardia admitted in Northern Jiangsu People's Hospital during January 2020 to January 2022 were enrolled and then randomly divided into dronedarone group(n=57),metoprolol group(n=55)and combined group(dronedarone+metoprolol,n=48).The frequency,duration and symptom changes of arrhythmia were compared before and after treatment.Results After 3 and 6 months of administration,the total effective rate was significantly higher in the combination group than the dronedarone group and the metoprolol group(P＜0.05).The frequency of atrial fibrillation(AF)attacks[(2.31±1.78)/48 h vs(11.56±18.68)/48 h],AF duration[(4.86±6.73)h/48 h vs(10.92±9.61)h/48 h],atrial flutter(AFL)attacks[(2.33±1.53)/48 h vs(4.33±1.53)/48 h]and AFL duration[(5.15±4.87)h/48 h vs(21.54±20.08)h/48 h]in the combined group,and AFL duration[(2.75±1.94)h/48 h vs(10.29±8.04)h/48 h]in the dronedarone group were reduced after 6 months of treatment(P＜0.05).Conclusion In the treatment of atrial tachycardia,dronedarone combined with low dose metoprolol can not only obviously improve symptoms,but also significantly reduce the atrial premature and atrial tachycardia attacks,decrease the number and duration of AF and AFL attacks,and control heart rate effectively.
