Expression of serological indicators and correlation with severity of coronary artery disease in elderly patients
10.3969/j.issn.1009-0126.2024.03.003
- VernacularTitle:血清学指标在老年冠心病患者中的表达与冠状动脉病变程度的相关性
- Author:
Fucheng ZHANG
1
;
Danyang CHANG
;
Zhifang WANG
;
Zhiqiang LIU
Author Information
1. 453000 新乡市中心医院(新乡医学院第四临床学院)心血管内科
- Keywords:
coronary disease;
chemokine CCL3;
angiography;
computed tomography angiography;
coronary stenosis;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of soluble tyrosine kinase-1(sFlt-1)and chemokine C-C ligand 3(CCL3)in serum of patients with coronary heart disease(CHD)and their correlation with the severity of the disease.Methods A total of 230 elderly CHD patients admitted to the De-partment of Cardiovascular Medicine of Xinxiang Central Hospital from November 2020 to No-vember 2022 were collected as the study subjects(CHD group),and according to their Gensini score,they were divided into mild(n=89),moderate(n=95),and severe(n=46)CHD sub-groups.Another 230 healthy individuals who taking physical examination during the same period served as the control group.ELISA was applied to measure serum levels of sFlt-1 and CCL3.ROC curve was plotted to analyze the diagnostic values of serum sFlt-1 and CCL3 levels for CHD.Pear-son correlation analysis was employed to analyze the relationship between serum sFlt-1 and CCL3 levels and the CHD severity.Results The serum levels of sFlt-1 and CCL3 were obviously higher in the CHD group than the control group(121.71±29.80 ng/L vs 98.70±17.57 ng/L,18.22± 5.41 ng/L vs 13.68±3.89 ng/L,P＜0.01).ROC curve analysis showed that the AUC value of the two indicators combined together was significantly greater than that of them alone in diagnosis of CHD(0.886 vs 0.791,0.775,P＜0.01).The serum levels of sFlt-1 and CCL3 were increased along with the severity of the disease and Gensini score when the levels and the score were compared among the mild,moderate and severe subgroups(P＜0.05).Pearson correlation analysis indicated that the serum levels of sFlt-1 and CCL3 were positively correlated with the Gensini score(r=0.420,r=0.479,P＜0.01).Conclusion The levels of serum sFlt-1 and CCL3 are obviously ele-vated in CHD patients,and closely associated with the severity of coronary lesions.
