Value of metoprolol combined with Wenxin Keli in treatment of atrial tachycardia after catheter ablation due to atrial fibrillation
10.3969/j.issn.1009-0126.2024.03.002
- VernacularTitle:美托洛尔联合稳心颗粒治疗心房颤动患者导管消融术后房性心动过速的价值
- Author:
Huiyang GU
1
;
Xiang GU
;
Ye ZHU
Author Information
1. 450052 郑州大学第五附属医院心血管内二科
- Keywords:
atrial fibrillation;
tachycardia,ectopic atrial;
catheter ablation;
metoprolol;
Wenxin Keli;
prospective studies
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(3):245-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic value of metoprolol combined with Wenxin Keli(a Chinese patent drug)on atrial tachycardia(AT)after catheter ablation in patients with atrial fibrillation(AF).Methods A total of 290 patients who were diagnosed with AF and underwent catheter ablation successfully in the Department of Cardiovascular Medicine of Northern Jiangsu People's Hospital from May 2018 to January 2022 were enrolled,and were randomly divided into Wenxin Granule group(Group W),metoprolol group(Group M),combined group(Group MW)and blank control group(Group C).The times of AT,heart beats during the longest AT episode,average heart rate and adverse reactions were compared among the 4 groups.Results The mean heart rate,episodes of AT,heart beats during the longest AT episode,and numbers of premature atrial contractions(PAC)of class Ⅰ,Ⅱ and Ⅲ in Group C in 1 year after operation were all sig-nificantly higher than the baseline levels(P＜0.01),so were in the Group W,Group M and Group MW(P＜0.01).Group MW had obviously lower mean heart rate,episodes of AT,heart beats dur-ing the longest AT episode,and numbers of PAC of class Ⅰ,Ⅱ and Ⅲ when compared with Group W and Group M(P＜0.05).There was no significant difference in the total incidence of ad-verse reactions in Group W,Group M and Group MW(7.1％vs 13.9％vs 8.9％,P=0.301).Con-clusion Metoprolol combined with Wenxin Keli can be used to treat AT after AF catheter abla-tion.The combination can effectively reduce the average heart rate,episodes of AT,numbers of PAC and heart beats during the longest AT episode,and thus decrease the recurrence of postopera-tive AF with high safety.
