Clinical study of ulinastatin in prevention and treatment of CIAKI in elderly coronary heart disease patients with CKD
10.3969/j.issn.1009-0126.2024.02.009
- VernacularTitle:乌司他丁防治老年冠心病合并慢性肾脏病患者对比剂诱导的急性肾损伤的临床研究
- Author:
Ying LI
1
;
Jian SHEN
;
Xin ZHANG
;
Boning ZHOU
;
Yang JIAO
;
Henan LIU
;
Zhenhong FU
Author Information
1. 100853 北京,解放军总医院第一医学中心心内科
- Keywords:
coronary disease;
nephrosis;
acute kidney injury;
contrast media;
angiography;
ulinastatin
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective and treatment role of ulinastatin(UTI)on con-trast-induced acute kidney injury(CIAKI)in the elderly with coronary heart disease(CHD)and chronic kidney diseases(CKD).Methods A total of 321 elderly CHD inpatients complicated with CKD undergoing coronary angiography admitted in the First Medical Center of Chinese PLA Gen-eral Hospital from November 2021 to November 2022 were enrolled consecutively and then divid-ed into UTI group(n=161)and hydration group(n=160).Their cardiac and renal function pa-rameters were collected and analyzed before and 2 d after intervention.The changes in above pa-rameters and incidence of CIAK were observed and compared between the two groups.Results In 2 d after intervention,the UTI group had significantly lower Scr,urea,CysC,homocysteine and NT-proBNP,but higher eGFR than the hydration group(P＜0.01).There were 62 patients(62/321,19.3％)developing CIAKI,including 17 from the UTI group and 45 from the hydration group,and statistical difference was observed in the incidence(10.6％vs 28.1％,P＜0.01).For the patients with comorbidities of hypertension,diabetes,hyperlipidemia and hyperuricemia,the incidence of CIAKI was obviously lower in the UTI group than the hydration group(P＜0.01).Multivariate logistic regression analysis showed that UTI was an independent protective factor for occurrence of CIAKI(OR=0.348,95％CI:0.180-0.673,P=0.001).Conclusion UTI can im-prove renal function and reduce the risk of CIAKI in elderly CHD patients with CKD.
