Prognostic value of soluble CD146 in elderly patients with acute ST segment elevation myocardial infarction after PCI
10.3969/j.issn.1009-0126.2024.02.007
- VernacularTitle:老年急性ST段抬高型心肌梗死患者介入治疗后可溶性CD146水平的预后价值
- Author:
Rongrong LU
1
;
Lixue BO
;
Kelimu WUMAIERJIANG
Author Information
1. 844000 新疆喀什地区第二人民医院心内科
- Keywords:
myocardial infarction;
percutaneous coronary intervention;
prognosis;
CD146 antigen
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(2):147-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of peripheral blood sCD146 as a long-term survival ben-efit marker in elderly patients with acute ST segment elevation myocardial infarction(ASTEMI)after PCI.Methods A total of 210 patients who were diagnosed with ASTEMI and underwent PCI in our hospital from January 2021 to July 2022 were enrolled,and according to the postopera-tive sCD146 level,they were divided into low-,medium-and high-level groups(69,65 and 76 cases respectively).All of them were followed up,with endpoint events including all cause death,cardiac death,and major adverse cardiovascular events(MACE).Kaplan-Meier survival curve was plotted to compare the cumulative survival rate of each group,and COX regression analysis was used to analyze the relationship between peripheral blood sCD146 level and prognosis.Results The mor-tality rate and MACE incidence were significantly higher in the high-level group than the low-and medium-level groups(P＜0.05).Kaplan-Meier curve analysis showed that the high-level group had obviously lower cumulative survival rate than the other two groups(P＜0.05).COX regres-sion analysis revealed that the sCD146 level in peripheral blood after PCI was independently cor-related with the occurrence of death in ASTEMI patients after PCI(OR=1.530,95％CI:1.144-2.044,P=0.004).Conclusion The peripheral blood level of sCD146 is closely related to long-term survival benefits in ASTEMI patients after PCI,and sCD146 can be used as a biomarker to evaluate their long-term survival benefits.
