Expression of miR-182-5p in patients with chronic heart failure and its correlation with left ventricular remodeling and prognosis
10.3969/j.issn.1009-0126.2024.02.004
- VernacularTitle:慢性心力衰竭患者微小RNA-182-5p表达水平及其与左心室重构和预后的相关性
- Author:
Xuelu TANG
1
;
Lei GUI
;
Jie ZHENG
;
Xiuhua DI
Author Information
1. 252000 聊城市人民医院心脏彩超室
- Keywords:
heart failure;
circulating microRNA;
prognosis;
ventricular remodeling;
forecasting;
correlation of data;
miR-182-5p
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(2):132-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum expression level of miR-182-5p in patients with chronic heart failure(CHF),and analyze its correlation with left ventricular remodeling and prog-nosis.Methods A total of 138 CHF patients admitted to Liaocheng People's Hospital from Janu-ary 2019 to December 2021 were enrolled as CHF group,and another 120 healthy volunteers who took physical examinations at the same time served as the healthy group.The expression level of miR-182-5p in serum was detected in the two groups.Pearson analysis was used to analyze the correlation between its expression level and left ventricular remodeling.ROC curve was plotted to analyze the diagnostic value of miR-182-5p expression level.During 1 year of follow-up,their sur-vival status was collected and analyzed in the CHF patients.The prognostic value of miR-182-5p expression level was evaluated by Kaplan-Meier survival curve.Results The CHF patients had significantly lower LVEF value,but higher left ventricular remodeling index(LVRI)and miR-182-5p expression level than the healthy group(P＜0.05,P＜0.01).The expression level of miR-182-5p was negatively correlated with LVEF(r=-0.496,P=0.000)and positively with LVRI(r=0.460,P=0.000).The AUC value of miR-182-5p expression level in diagnosing CHF was 0.964,the cutoff value was 0.905,the sensitivity was 91.3％,and the specificity was 86.7％.Kaplan-Meier survival curve analysis showed that the high expression level of miR-182-5p could predict the overall survival of CHF patients(P=0.039).Conclusion The expression level of miR-182-5p is higher in CHF patients than healthy people,and the patients with higher level indi-cate more serious left ventricular remodeling.Detecting the expression level of miR-182-5p is help-ful for the diagnosis and poorgnosis prediction of CHF patients.
