Efficacy of intravenous thrombolysis combined with Solitaire FR stent thrombectomy in treatment of acute LAO cerebral infarction
10.3969/j.issn.1009-0126.2024.01.017
- VernacularTitle:静脉溶栓联合Solitaire FR型支架取栓术对急性大动脉闭塞性脑梗死患者的疗效分析
- Author:
Peng WANG
1
;
Hongbo WEN
;
Jiankang HUANG
;
Rongcheng ZOU
;
Jie DING
;
Jie WANG
;
Yongwei SHU
;
Pengyu DING
Author Information
1. 211200 南京市溧水区人民医院(东南大学附属中大医院溧水分院)神经内科
- Keywords:
brain infarction;
embolectomy;
fibrinolytic agents;
tissue plasminogen activator;
prog-nosis;
Solitaire FR stent
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of intravenous thrombolysis combined with Solitaire FR stent thrombectomy on vascular recanalization,neurologic function and prognosis in patients with acute cerebral infarction(ACI)due to large artery occlusion(LAO).Methods A total of 172 patients with ACI-LAO treated in our department between October 2020 and March 2023 were retrospectively enrolled.According to treatment regimens,they were assigned into control group(86 cases,alteplase intravenous thrombolysis)and study group(86 cases,alteplase intravenous thrombolysis combined with Solitaire FR stent thrombectomy).Vascular recanalization,neurolog-ic function,cerebral perfusion and occurrence of adverse events were compared between the two groups.After 90 d of follow-up,their prognosis was evaluated with modified Rankin scale.Results There was no significant difference in success rate of vascular recanalization between the two group(P＞0.05),but complete recanalization rate was statistically higher in the study group than the control group(68.60％vs 50.00％,P＜0.05).The study group had obviously lower NHISS scores at 7 and 14 d after treatment,higher cerebral blood volume and cerebral blood flow,but shorter mean transit time when compared with the control group(P＜0.05,P＜0.01).No notable difference was observed in the total incidence of adverse events between them(P＞0.05).After 90 d of follow-up,the proportion of good prognosis was higher in the study group than the control group(80.23％vs 63.95％,P＜0.05).Conclusion Intravenous thrombolysis combined with Soli-taire FR stent thrombectomy shows better efficacy in ACI-LAO patients,with better vascular re-canalization and great improvements in neurologic function and prognosis.
