Correlation between serum beta 2-microglobulin level and cerebral microbleeds in the elderly
10.3969/j.issn.1009-0126.2024.01.014
- VernacularTitle:老年人群血清β2微球蛋白水平与脑微出血的相关性分析
- Author:
Cunsheng WEI
1
;
Xiaorong YU
;
Yuan CHEN
;
Juan JI
;
Xuemei CHEN
Author Information
1. 211100 南京医科大学附属江宁医院神经内科
- Keywords:
cerebral hemorrhage;
beta 2-microglobulin;
magnetic resonance imaging;
risk factors;
forecasting;
retrospective studies;
cerebral microbleeds
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum beta 2-microglobulin(B2M)level and cerebral microbleeds(CMB)in the elderly.Methods A retrospective analysis of 636 elderly patients with chronic diseases admitted to the Department of Neurology of our hospital from Janu-ary 2020 to November 2022 was made.On the second day after admission,venous blood samples were collected to detect the serum B2M level,and brain magnetic resonance susceptibility weigh-ted imaging was performed.Then these patients were assigned into CMB group(82 cases)and CMB-free group(554 cases).Binary logistic regression analysis was employed to identify the inde-pendent risk factors for CMB.Results Binary logistic regression analysis showed that serum B2M level was an independent risk factor for CMB in elderly patients(Model 1:β=0.179,OR=1.196,95％CI:1.017-1.407,P=0.031;Model 2:β=0.215,OR=1.240,95％CI:1.048-1.468,P=0.012)after adjusting confounding factors.ROC curve analysis indicated that the optimal cutoff value of serum B2M level in diagnosing CMB was 1.805 mg/L,with a sensitivity of 70.7％and a specificity of 52.5％,and an AUC value of 0.657(95％CI:0.595-0.719,P＜0.01).Conclusion The increment of serum B2M level is closely related to CMB in the elderly population,so the pro-tein can be used as one of indicators for prediction of CMB in the population.
