Correlation between total burden of cerebral small vessel disease and poor prognosis of branch atheromatous disease in the elderly
10.3969/j.issn.1009-0126.2024.01.012
- VernacularTitle:老年脑小血管病总负荷与穿支动脉粥样硬化病预后不良的相关性研究
- Author:
Qiuyun LU
1
;
Qiang LI
;
Limei CAO
;
Chen PENG
;
Xu CHEN
Author Information
1. 200235 上海市第八人民医院神经内科
- Keywords:
cerebral small vessel diseases;
intracranial arteriosclerosis;
prognosis;
total burden of cerebral small vessel disease
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(1):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the total burden of cerebral small vessel disease and poor prognosis of branch atheromatous disease(BAD)in elderly patients.Methods A total of 114 BAD patients admitted to Shanghai Eighth People's Hospital between January 2021 and March 2023 were enrolled,and according to mRS score at 90 d after onset,they were divided into a good prognosis group(mRS score ≤2,67 cases)and a poor prognosis group(mRS score＞2,47 cases).The clinical and imaging characteristics were analyzed,and the relationship between total cerebral small vessel disease burden and clinical prognosis of BAD was investigated using lo-gistic regression analysis.ROC curve analysis was used to determine the threshold of the total cere-bral small vessel disease burden for predicting adverse outcomes and to evaluate its sensitivity and specificity.Results The good prognosis group had younger age,smaller proportion of diabetes,lower SBP,NIHSS score at admission and white matter hyperintensities,and reduced ratio of cerebral microbleeds than the poor prognosis group(P＜0.05,P＜0.01).Statistical difference was observed in the total cerebral small vessel disease burden between the two groups(P＜0.01).Binary logistic regression analysis showed that the total cerebral small vessel disease burden score and NIHSS score at admission were independent predicators of poor prognosis in BAD patients(OR=3.350,95％CI:1.439-7.798,P=0.005;OR=2.814,95％CI:1.586-4.993,P=0.001).ROC curve analysis indicated that the total cerebral small vessel disease burden had a cut-off val-ue of 1.5,and the sensitivity and specificity for predicting poor prognosis was 63.8％and 86.6％,respectively,for BAD patients.Conclusion The total cerebral small vessel disease burden is an in-dependent predictor for poor prognosis of BAD patients.
