Correlation between geriatric nutritional risk index and adverse events in elderly hemodialysis patients
10.3969/j.issn.1009-0126.2024.01.011
- VernacularTitle:老年血液透析患者不良预后事件与老年营养危险指数相关性研究
- Author:
Zhihua SHI
1
;
Yidan GUO
;
Pengpeng YE
;
Chunxia ZHANG
;
Xiaoling ZHOU
;
Meng JIA
;
Xiyou ZHANG
;
Yang LUO
Author Information
1. 100038 首都医科大学附属北京世纪坛医院肾内科
- Keywords:
renal dialysis;
malnutrition;
correlation of data;
prognosis;
prospective studies;
heart disease risk factors;
geriatric nutritional risk index
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between geriatric nutritional risk index(GNRI)and adverse outcomes in elderly patients undergoing maintenance hemodialysis(MHD).Methods A prospective cohort trial was conducted on 337 MHD patients aged ≥60 years in hemodialysis centers of 11 hospitals in Beijing from April to June 2017.Their baseline data were collected,and they were divided into non-malnutrition(GNRI≥98,226 cases),mild malnutrition(92≤GNRI＜98,81 cases),and major malnutrition groups(GNRI＜92,30 cases).All of them were followed up until June 2018.The endpoint events were all-cause mortality and cardiovascular disease(CVD)mortality.Kaplan-Meier survival analysis was used to compare the cumulative survival rate among the 3 groups.Multivariate Cox regression model was employed to analyze the relationship of GNRI with all-cause and CVD mortality.Results The mild and major malnutrition groups had significantly lower BMI,serum albumin level and GNRI(P＜0.01).During the median follow-up of 52(4.4-52.0)weeks,56(16.6％)patients died of all-cause death and 25(44.6％)of CVD death.Kaplan-Meier survival curve showed significant differences in all-cause mortality(x2=30.484,P＜0.01)and CVD mortality(x2=22.398,P＜0.01)in the 3 groups.Multivariate Cox regression analysis indicated that,as a continuous variable,elevated GNRI was a protective factor for all-cause mortality(HR=0.910,95％CI:0.870-0.952,P=0.000)and CVD mortality(HR=0.895,95％CI:0.852-0.940,P=0.000),and as a categorical variable,mild and major malnutri-tion were independently correlated with all-cause and CVD mortality(P＜0.05).Conclusion GNRI is an independent risk factor for all-cause and CVD mortality in elderly MHD patients.Mo-nitoring the nutritional status using GNRI can predict the risk of adverse prognosis.
