Impact of CSVD combined with cerebral large artery atherosclerosis on cognitive function in patients with advanced age
10.3969/j.issn.1009-0126.2023.12.023
- VernacularTitle:高龄患者脑小血管病合并脑大动脉粥样硬化对认知影响的对比研究
- Author:
Lin LI
1
;
Jian SONG
;
Wei LIU
;
Jiani LIU
;
Xiujuan CHEN
;
Xiaojin GE
;
Zeng LI
;
Lin DING
;
Fang WANG
Author Information
1. 430014 武汉市中心医院老年科
- Keywords:
cerebral small vessel diseases;
intracranial arteriosclerosis;
cognition;
retrospective studies;
magnetic resonance imaging
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(12):1328-1331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of overall burden of cerebral small vessel disease(CSVD)combined with intracranial large artery atherosclerosis(ICAS)on cognitive function in very old patients.Methods A total of 178 advanced elderly patients admitted to Department of General Medicine of Wuhan Central Hospital between January 2013 and December 2022 were re-cruited in this retrospective study.According to the results of Montreal Cognitive Assessment Scale,they were divided into dementia group(n=83)and non-dementia group(n=95).All pa-tients underwent brain MRI imaging,MRI susceptibility weighted imaging and cerebral angiogra-phy.Based on these imaging findings of MRI,the effect of total burden score of CSVD and athero-sclerosis on cognition were evaluated.The volumes of 14 different gyri in the left and right brain were measured in the patients with CSVD burden score ≤2 and those ≥3.Results There were significantly more patients with numbers of microbleeding foci＞10 and lacunar foci ≥5 in the dementia group than the non-dementia group(P＜0.01).But,no statistical difference was seen in intracranial and extracranial arterial stenosis between the two groups(P＞0.05).The volumes of left and right anterior cingulate gyrus,left and right paracingulate cortex,right hippocampus,left parahippocampal gyrus,right transverse temporal gyrus and left inferior temporal gyrus were no-tably smaller in the CSVD score ≥3 group than the CSVD ≤2 group(1723.444 vs 1867.167,1590.167 vs 1595.670,1481.466 vs 1509.540,1543.831 vs 1585.505,1038.345 vs 1305.831,1220.525 vs 1392.352,P＜0.05).Conclusion Cognitive function in the advanced elderly is mainly affected by the burden of CSVD,and atherosclerotic stenosis of large arteries is not the main fac-tor affecting cognitive function.The total burden of CSVD is correlated with atrophy of some gyri.
