Safety and effectiveness of bridging therapy in elderly acute stroke patients with posterior circulation large vessel occlusion
10.3969/j.issn.1009-0126.2023.12.017
- VernacularTitle:桥接治疗对老年后循环大血管闭塞的急性脑卒中患者的安全性和有效性研究
- Author:
Zhiguang LIU
1
;
Zaili LI
;
Wenhong ZHI
;
Ning HAO
;
Xu CAO
;
Peiwei CAO
Author Information
1. 221009 徐州市中心医院神经内科
- Keywords:
stroke;
brain infarction;
balloon embolectomy;
prognosis;
bridging therapy
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(12):1302-1305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the safety and effectiveness of bridging therapy in elderly patients with acute stroke due to posterior circulation large vessel occlusion.Methods A total of 160 eld-erly patients with acute stroke caused by posterior circulation large vessel occlusion admitted to our department were prospectively recruited and randomly divided into bridging group(n=80)and control group(n=80).The bridging group received thrombolysis treatment and then mechan-ical thrombectomy.The control group received mechanical thrombectomy directly.Prognosis and adverse reactions were compared between the two groups.Results The NIHSS score and BATMAN score after treatment were significantly decreased in both groups(P＜0.01),and the two scores were obviously lower in the bridging group than the control group(6.54±1.23 vs 7.12± 0.98,2.12±0.34 vs 2.87±0.44,P＜0.01).There was no statistical difference in the conversion rate of bleeding after cerebral infarction between the two groups(5.00％vs 3.75％,P＞0.05).The number of intraoperative thrombus removal was significantly lower in the bridging group than the control group(2.43±0.33 vs 2.98±0.41,P＜0.01).Remarkable difference was observed in the mRS score between the two groups after treatment(P＜0.05),with the proportion of mRS score ranging from 0 to 1 larger in the bridging group than the control group(52.50％vs 27.50％,P＜0.05).Conclusion Bridging thrombolysis can significantly improve the neurological function in elderly patients with acute stroke due to posterior circulation occlusion.
