Diagnostic value of CHA2DS2-VASc score combined with two serum factors for non-valvular atrial fibrillation complicated with ACI
10.3969/j.issn.1009-0126.2023.12.015
- VernacularTitle:CHA2DS2-VASc评分联合两种血清因子对非瓣膜性心房颤动合并急性脑梗死的诊断价值
- Author:
Huanqing YU
1
;
Qingyi XU
;
Dongfang GUO
;
Hua REN
Author Information
1. 266001 青岛市第五人民医院120急救站
- Keywords:
atrial fibrillation;
brain infarction;
angiopoietin-like 4 protein;
ubiquitin thiolesterase;
diagnosis;
risk factors;
CHA2DS2-VASc score
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(12):1293-1296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in serum levels of angiopoietin-like protein 4(ANGPTL4)and ubiquitin carboxyl terminal hydrolase-1(UCH-L1),and CHA2DS2-VASc score in patients with non-valvular atrial fibrillation(NVAF)and acute cerebral infarction(ACI),and their diagnostic value.Methods A total of 162 NVAF patients treated in our hospital from Janu-ary 2021 to January 2023 were enrolled and divided into a combined group(45 cases)and a non-combined group(117 cases)according to having ACI or not.General clinical information,CHA2DS2-VASc scores,and serum levels of ANGPTL4 and UCH-L1 were collected and detected.Spearman correlation analysis was applied to evaluate the correlation of ANGPTL4,UCH-L1 and CHA2DS2-VASc score.Multivariate logistic regression analysis was performed to identify the in-fluencing factors of NVAF combined with ACI.ROC curve was plotted to evaluate the diagnostic value of serum ANGPTL4,UCH-L1,and CHA2DS2-VASc score for NVAF combined with ACI.Results The ANGPTL4 level was significantly lower,and the UCH-L1 level and CHA2DS2-VASc score were obviously higher in the combined group than the non-combined group(P＜0.05).In the patients with NVAF combined with ACI,serum ANGPTL4(r=-0.548,P＜0.05)and UCH-L1(r=0.400,P＜0.05)levels were negatively and positively correlated with CHA2DS2-VASc score,respectively.ANGPTL4,UCH-L1 and CHA2DS2-VASc were the risk fac-tors for ACI in NVAF patients(P＜0.05,P＜0.01).The AUC value of combined serum ANGPTL4 and UCH-L1 levels and CHA2DS2-VASc score for diagnosing NVAF complicated with ACI was 0.926(95％CI:0.874-0.961).Conclusion Combined detection of serum AUCH-L1 and NGPTL4 levels and CHA2DS2-VASc score can significantly improve the diagnostic value of NVAF patients with ACI.
