Correlation between cardiac dysfunction and cognitive impairment in patients with ischemic heart disease
10.3969/j.issn.1009-0126.2023.12.003
- VernacularTitle:缺血性心脏病患者心功能受损与认知功能障碍的相关性研究
- Author:
Chong ZHENG
1
;
Yadong CUI
;
Shanshan GU
;
Bixiao CUI
;
Jie MA
;
Jin SI
;
Keling XIAO
;
Jing LI
;
Jie LU
Author Information
1. 100053 北京,首都医科大学宣武医院放射与核医学科磁共振成像脑信息学北京市重点实验室
- Keywords:
cognitive dysfunction;
myocardial ischemia;
positron-emission tomography;
retrospec-tive studies;
correlation of data;
heart disease risk factors
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2023;25(12):1240-1244
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between left ventricular dysfunction and cogni-tive impairment in patients with ischemic heart disease(IHD),and explore the potential patho-genesis of cognitive impairment in IHD patients.Methods Fifty IHD patients who underwent hybrid cardiac PET/MR in our hospital from September 2020 to December 2022 were retrospec-tively enrolled in this study.According to their Montreal cognitive assessment(MoCA)scores,they were categorized into a cognitively normal group(21 cases,MoCA score ≥26)and a cogni-tively declining group(29 cases,MoCA score＜26).All patients received 13N-NH3·H2O myocar-dial perfusion imaging and 18F-FDG cardiac PET/MR to evaluate cardiac function and obtain car-diac imaging parameters.Spearman correlation analysis was applied to analyze the correlation between cardiac PET/MR parameters and MoCA scores.General linear model analysis was applied to analyze the correlation between MoCA scores and cardiac PET/MR parameters after adjusting for co variates.Results Compared with the cognitively normal group,the patients in the cognitively declining group had significantly lower stroke volume[56.95(47.51,77.64)ml vs 82.66(73.88,92.92)ml,P=0.001],stroke volume index[34.07(28.93,43.20)ml/m2 vs 44.28(38.06,49.49)ml/m2,P=0.008],cardiac output[3.92(3.18,5.34)L/min vs 5.13(4.58,5.67)L/min,P=0.007],and cardiac index[(2.42±0.68)L/(min·m2)vs(2.78±0.39)L/(min·m2),P=0.021].Spearman correlation analysis revealed that MoCA score was positively correlated with stroke volume(r=0.497,P=0.001),stroke volume index(r=0.365,P=0.009)and cardiac output(r=0.361,P=0.010).After adjusting for sex,age,education level and vascular risk factors,MoCA score re-mained positively correlated with stroke volume(r=0.497,P=0.003).Conclusion Systemic hy-poperfusion in IHD patients may be one of the mechanisms leading to cognitive impairment.
