Research progress on roles of IL-17A in sepsis related organ injury

VernacularTitle:白细胞介素17A在脓毒症相关脏器损伤中的研究进展
Author: Haodi GU ¹ ; Hui LIN ; Yue SHAN
Author Information

1. 绍兴文理学院医学院，绍兴312000
Keywords: Interleukin 17A; Sepsis; Organ injury; Signaling pathway
From: Chinese Journal of Clinical Infectious Diseases 2024;17(1):75-80
CountryChina
Language:Chinese
Abstract: Sepsis is a pathological condition in which the body’s response to infection is dysfunctional and may lead to life-threatening organ failures as one of the leading causes of death worldwide. However，there is still a lack of effective prevention and treatment for sepsis. IL-17A is an inflammatory cytokine produced primarily by activated T cells and is involved in host defense，tissue repair，the pathogenesis of inflammatory diseases，and the progression of cancer. This article reviews the recent research progress on the roles of IL-17A in sepsis-related organ damage，and its potentials as a novel therapeutic target for the clinical treatment of sepsis.