Research progress of FAPI radionuclide imaging in cardiovascular diseases

VernacularTitle:FAPI核素显像在心血管疾病中的研究进展
Author: Jiali HAN ¹ ; Li LI ; Ping WU ; Jianbo SONG ; Sijin LI
Author Information

1. 山西医科大学第一医院核医学科，太原　030001
Keywords: Cardiovascular diseases; Antagonists and inhibitors; Membrane proteins; Fibroblasts; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2024;44(4):244-248
CountryChina
Language:Chinese
Abstract: Myocardial fibrosis is an important pathological process in the development of cardiovascular diseases, which is closely related to the prognosis of patients. Activated cardiac fibroblasts (CFs) are the main effector cells, whose surface specifically overexpress fibroblast activation protein (FAP). Radionuclide-labeled FAP inhibitors (FAPIs) can specifically bind to FAP to visualize activated CFs in vivo, showing preliminary clinical application in the early diagnosis, prognosis prediction and interventional guidance of various cardiovascular diseases. This article reviews the progress of researches on the application of radionuclide-labeled FAPIs in cardiovascular diseases imaging.