The effect of topical oxygen therapy on the intervention of patients with diabetic foot ulcers:a Meta-analysis
10.3761/j.issn.0254-1769.2023.24.005
- VernacularTitle:局部氧疗对糖尿病足溃疡患者干预效果的Meta分析
- Author:
Xiaoran XIE
1
;
Rong XU
;
Jing ZHANG
;
Jing TAO
;
Xuna BIAN
;
Jinjie HOU
Author Information
1. 430030 武汉市 华中科技大学同济医学院附属同济医院护理部
- Keywords:
Topical Oxygen Therapy;
Diabetic Foot;
Foot Ulcer;
Meta-Analysis;
Evidence-Based Nursing
- From:
Chinese Journal of Nursing
2023;58(24):2976-2983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically analyze and compare studies related to the intervention effect of topical oxygen therapy on patients with diabetic foot ulcers,and provide references for nursing practice.Methods We searched PubMed,Embase,Web of Science,CENTRAL,CINAHL,Clinical Trial,China Biomedical Literature Database,CNKI,Wanfang Database,and VIP from inception to February 1,2023,to collect studies on the effect of topical oxygen therapy interventions on patients with diabetic foot ulcers.2 researchers independently screened the litera-ture,and extracted the information,and a meta-analysis of the included literature was performed by RevMan 5.4 software.Results 8 studies with 622 patients were included.Meta-analysis results showed that compared with con ventional care,topical oxygen therapy improved the response rate[RR=1.59,95％CI(1.16,2.17),P=0.004]and the reduction of diabetic foot ulcer area[MD=28.78,95％CI(14.83,42.73),P＜0.001],and the method did not increase the incidence of adverse events[RR=0.83,95％CI(0.63,1.10),P=0.190],but the difference was not statistically significant in terms of healing time[MD=9.86,95％CI(-15.39,35.11),P=0.440].Conclusion Topical oxygen therapy helps to im-prove the response rate and reduce the ulcer size in patients with diabetic foot ulcers with a better safety profile,but the effect of the intervention on healing time is unclear.Further high-quality randomized controlled trials should be conducted in the future to validate the efficacy of topical oxygen therapy in patients with diabetic foot ulcers.
