Seasonal and regional variations in the causes of anaphylaxis in Korean adults.
10.4168/aard.2015.3.3.187
- Author:
Yeon Kyung LEE
1
;
Mi Kyeong KIM
;
Hye Ryun KANG
;
Tae Bum KIM
;
Seong Wook SOHN
;
Hye Kyung PARK
;
Young Il KOH
;
Gwang Cheon JANG
;
Cheol Woo KIM
;
Young Koo JEE
;
Gyu Young HUR
;
Joo Hee KIM
;
Sang Heon KIM
;
Gil Soon CHOI
;
Soo Keol LEE
;
Hae Sim PARK
;
Young Min YE
Author Information
1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. ye9007@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Anaphylaxis;
Adult;
Etiology;
Seasons;
Geographic locations
- MeSH:
Adult*;
Allergens;
Anaphylaxis*;
Bees;
Bites and Stings;
Busan;
Contrast Media;
Female;
Geographic Locations;
Gyeonggi-do;
Hospitals, University;
Humans;
Insect Bites and Stings;
Jeollanam-do;
Korea;
Logistic Models;
Male;
Retrospective Studies;
Seasons*;
Seoul
- From:Allergy, Asthma & Respiratory Disease
2015;3(3):187-193
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate whether causes of anaphylaxis vary according to regions and seasons in Korean adults. METHODS: Based on previous retrospective studies of anaphylaxis between 2007 and 2011 at the 15 university hospitals. Regions were classified into 4 groups: region I, Seoul; region II, Gyeonggi; region III, Chungcheong; and region IV, Chonnam and Busan. The cases induced by 5 major allergens including drugs, food, bee sting, radiocontrast media, and exercise, were analyzed in the present study. RESULTS: Among a total of 1,661 cases reported (53% male, 45.9+/-16.0 years), 367 (22.2%), 706 (42.5%), 319 (19.2%), and 269 cases (16.2%) were enrolled in regions I, II, III, and IV, respectively. Of the 5 major allergens, drugs (37.3%) were the most frequently reported, followed by food (25.7%), bee sting (17.9%), radiocontrast media (12.9%), and exercise (6.2%). There was no significant difference in the total occurrence of anaphylaxis in 4 seasons (374 in spring, 460 in summer, 460 in autumn, and 367 in winter). Multiple logistic regression analysis revealed that drug-induced anaphylaxis was significantly associated with the winter season (odds ratio [OR] 1.0 vs. OR 0.597, P<0.05 for spring; OR 1.0 vs. OR 0.481, P<0.01 for summer; OR 1.0 vs. OR 0.653, P<0.05 for autumn). Food-associated anaphylaxis was mainly reported in region I, whereas the frequency of insect sting was relatively higher in regions II, III, and IV than in region I. Older age and female gender were significantly associated with drug-induced anaphylaxis. CONCLUSION: Specific causative allergens of anaphylaxis in adults may vary according to age, gender, region, and season in Korea.
