Advancements in research on the regulation of bone metabolism by adipose browning
10.3760/cma.j.cn121113-20230928-00210
- VernacularTitle:脂肪棕色化调节骨代谢的研究进展
- Author:
Zemin LIU
1
;
Dong WANG
;
Xin LYU
;
Yonghong ZHANG
Author Information
1. 山西医科大学第二医院骨科，太原 030001
- Keywords:
Bone;
Metabolism;
Orthopedics;
Adipose Tissue, Brown;
Review
- From:
Chinese Journal of Orthopaedics
2024;44(3):186-192
- CountryChina
- Language:Chinese
-
Abstract:
Bone metabolism includes the processes of bone formation and bone resorption, both of which maintain bone metabolic homeostasis in the body. Adipose browning is a biological process that converts energy-storing white fat into thermogenic brown fat, which is induced by environment, exercise, nutrients, and signaling molecules. Adipose browning regulates bone metabolism in vivo and affects osteogenic and osteoblastic capacity through the secretion of adipokines such as fibroblast growth factor-21, adiponectin, insulin-like growth factor-1, and bone morphogenetic proteins. Adipose browning can also affect bone metabolism through immune pathways mediated by the gut microbiota. The browning ability of fat decreases in the aging body, which is related to the imbalance of bone metabolism in the state of osteoporosis. In children and adolescents, fat browning is active and bone metabolism is maintained in a healthy state. Exercise and supplementation of nutrients (capsaicin, resveratrol, quercetin, etc.) can promote the browning of adipose tissue and maintain brown adipose tissue, which plays a positive role in bone metabolism. In the future, it is of great significance to clarify the specific regulatory mode between adipose browning and bone metabolism for the treatment of bone metabolism-related diseases by intervening adipose browning.
