Research progress of organoids in liver regenerative medicine
10.3760/cma.j.cn113884-20230922-00087
- VernacularTitle:类器官在肝脏再生医学中的研究进展
- Author:
Liuyang ZHU
1
;
Sen LIU
;
Tao CUI
;
Long YANG
;
Chuanliang CHENG
;
Pinsheng HAN
;
Yamin ZHANG
Author Information
1. 天津医科大学一中心临床学院，天津 300070
- Keywords:
Organoids;
Regenerative medicine;
Liver
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Liver regenerative medicine can use functional liver cells to repair or replace damaged liver tissue and it is expected to be rapidly developed as an alternative treatment to liver transplantation. However, regenerative medicine requires cells with stable proliferation ability and liver cell characteristics. Liver organoids are derived from adult stem cells or pluripotent stem cells. They can be proliferated in large quantities and cultured for a long time in vitro, meanwhile maintain genetic stability, and simulate the structural and functional characteristics of organs in the body, providing a new strategy for liver regeneration. This article reviews liver organoids and their research progress in liver regenerative medicine, and discusses their application potential and existing limitations.
