The relationship of age-adjusted Charlson comorbidity index and prognosis of patients undergoing laparoscopic resection for hilar cholangiocarcinoma
10.3760/cma.j.cn113884-20230730-00016
- VernacularTitle:年龄校正的Charlson合并症指数与肝门部胆管癌患者腹腔镜手术切除后预后的关系
- Author:
Chiyu CAI
1
;
Liancai WANG
;
Lianyuan TAO
;
Dongxiao LI
;
Erwei XIAO
;
Guangjin TIAN
;
Guanbin LUO
;
Zhuangzhuang YAN
;
Yanbo WANG
;
Deyu LI
Author Information
1. 郑州大学人民医院肝胆胰腺外科，郑州 450003
- Keywords:
Klatskin tumor;
Prognosis;
Influencing factors;
Age-adjusted Charlson comorbidity index
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(1):33-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the impact of the age-adjusted Charlson comorbidity index (ACCI) on the prognosis of patients with hilar cholangiocarcinoma following laparoscopic surgical resection.Methods:Clinical data of 136 patients with hilar cholangiocarcinoma undergoing laparoscopic surgery at Zhengzhou University People's Hospital between January 2013 and January 2018 were retrospectively analyzed, including 81 males and 55 females, aged (63.6±9.8) years. Patients were divided into two groups based on the median ACCI score of 4.0: the high ACCI group (ACCI>4.0, n=49) and low ACCI group (ACCI≤4.0, n=87). The prognosis was compared between the two group. Univariate and multivariate Cox regression analyses were performed to analyze the effect of ACCI on survival after laparoscopic surgery. Results:The 1- and 3-year cumulative survival rates in low ACCI group were 87.4% and 48.3%, respectively, compared to 53.1% and 4.1% in high ACCI group ( χ2=27.97, P<0.001). Univariate Cox regression analysis indicated that ACCI >4.0 was associated with prognosis ( HR=3.73, 95% CI: 2.44-5.68, P<0.001). Multivariate Cox regression analysis also indicated that ACCI >4.0 was associated with an increased risk of postoperative mortality in patients with hilar cholangiocarcinoma ( HR=2.69, 95% CI: 1.65-4.37, P<0.001). Conclusion:The ACCI is a significant risk factor for survival of patients with hilar cholangiocarcinoma following laparoscopic surgery, which could facilitate a precise preoperative assessment of patient status and choice of surgical approach.
