Tumor-associated macrophages in the pancreatic cancer microenvironment: potential therapeutic targets

VernacularTitle:胰腺癌微环境中的肿瘤相关巨噬细胞：潜在的治疗靶点
Author: Shi DONG ¹ ; Xin LI ; Yan DU ; Wence ZHOU
Author Information

1. 兰州大学第二临床医学院，兰州　730000
Keywords: Pancreatic neoplasms; Tumor-associated macrophages; Tumor immunotherapy; Tumor microenvironment
From: Chinese Journal of Hepatobiliary Surgery 2023;29(12):955-960
CountryChina
Language:Chinese
Abstract: Pancreatic cancer is one of the deadliest gastrointestinal malignancies in the world. Although the standard of treatment has been improved, it is not enough to effectively improve the prognosis of patients. As a major component of tumor microenvironment, tumor-associated macrophage (TAM) plays an important role in the field of tumor development, invasion and metastasis, angiogenesis, chemotherapy resistance and immune escape, and are closely related to poor prognosis of patients. Therefore, in-depth exploration of the complex mechanism of TAM in pancreatic cancer immunotherapy may provide new insights into the regulation of pancreatic cancer microenvironment. This article comprehensively introduces the role and mechanism of TAM in the progression of pancreatic cancer, summarizes the pancreatic cancer treatment strategies for TAM and proposes further optimization schemes, hoping to provide a new direction and reference for TAM-based pancreatic cancer immunotherapy.