Research and application progress of organoids in liver cancer
10.3760/cma.j.cn113884-20230823-00046
- VernacularTitle:类器官在原发性肝癌中的研究及应用进展
- Author:
Zehao LIU
1
;
Chenxuan ZHANG
;
Keshuai DONG
;
Jia YU
Author Information
1. 武汉大学人民医院肝胆外科，武汉 430060
- Keywords:
Liver neoplasms;
Organoids;
Biomarkers;
Tumor microenvironment;
Neoplasm metastasis
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(12):945-949
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is a major global public health issue and currently the second leading cause of cancer death worldwide. The continuous changes in early cancer detection and treatment strategies have improved the overall survival rate of patients. Emerging organoid technologies have had a dramatic impact on cancer research in recent years, and tumor organoids are widely used in basic and translational cancer research. Tumor organoid culture technology will bridge the gap among molecular genetics, biology and clinical treatment. In this review, we discussed the recent different applications of liver organoids in liver cancer biology and clinical translation, involving liver cancer molecular studies, microenvironment and metastasis studies and drug screening trials, in order to provide a reference for clinical practice.
