Research progress in animal models of cholangiocarcinoma

VernacularTitle:胆管癌动物模型的研究进展
Author: Xiaojun SUI ¹ ; Dapeng ZHANG ; Qi ZHANG ; Jing XUN ; Ximo WANG
Author Information

1. 天津市急腹症器官损伤与中西医修复重点实验室　天津医科大学南开临床学院，天津　300100
Keywords: Bile duct neoplasms; Models, animal; Implantation models; Genetically engineered models
From: Chinese Journal of Hepatobiliary Surgery 2023;29(11):875-880
CountryChina
Language:Chinese
Abstract: Cholangiocarcinoma originates from bile duct epithelial cells and is a highly heterogeneous and aggressive malignant tumour. A deep understanding of the biological characteristics of the tumor can help to make progress in the treatment of cholangiocarcinoma. There are many types of animal models of cholangiocarcinoma, and different models can be induced according to different research purposes, including chemotoxic agent models, cholestatic models, implantation models, genetically engineered models, etc. This paper summarises the existing animal models of cholangiocarcinoma, compares their advantages and disadvantages as well as the application scenarios, and provides a reference for subsequent studies.