Risk factors for clinically relevant postoperative pancreatic fistula of pancreatic tumor in children
10.3760/cma.j.cn113884-20230402-00097
- VernacularTitle:儿童胰腺肿瘤手术后发生临床相关性术后胰瘘的影响因素分析
- Author:
Hong ZHANG
1
;
Jianxi BAI
;
Haiyan CHENG
;
Jun FENG
;
Shen YANG
;
Hong QIN
;
Huanmin WANG
;
Bing ZHANG
Author Information
1. 福建省儿童医院普外科，福州 350000
- Keywords:
Pancreatic neoplasms;
Risk factors;
Children;
Clinically relevant postoperative pancreatic fistula;
Duodenum-preserving pancreatic head resection
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(11):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the influencing factors of clinically relevant postoperative pancreatic fistula (CR-POPF) in children with pancreatic tumors after surgery.Methods:The clinical data of 123 children undergoing surgery for pancreatic tumor in Beijing Children's Hospital, Capital Medical University from January 2007 to March 2020 were retrospectively analyzed, including 39 males and 84 females, with a median age of 9.8 years (6.7 to 11.8). Patients without pancreatic fistula and with biochemical leakage were included in control group ( n=95), while patients with grade B and C pancreatic fistula were divided into CR-POPF group ( n=28). The independent influencing factors of CR-POPF were analyzed by univariate and multivariate logistic regression. Results:Among 123 children, 28 cases (22.8%) developed CR-POPF, including 24 cases (85.7%, 24/28) of grade B pancreatic fistula and 4 cases (14.3%, 4/28) of grade C pancreatic fistula. There were significant differences between CR-POPF and control groups in the age > 8 years and 4 months, tumor location, operation time >390 min and procedures (all P<0.05). Multivariate logistic regression analysis showed an increased risk of CR-POPF in children aged > 8 years and 4 months ( OR=8.226, 95% CI: 1.813-37.333, P=0.006) and undergoing duodenum-preserving pancreatic head resection (DPPHR) ( OR=3.353, 95% CI: 1.282-8.767, P=0.014). Conclusion:Age>8 years and 4 months and DPPHR are independent risk factors for CR-POPF in children with pancreatic tumors after surgery.
